Results of a large European inception cohort indicate that a minority of patients with microscopic colitis follow a quiescent disease course whereas the majority suffers from chronic active or relapsing disease with significantly impaired quality of life.
A large cohort study of veterans with IBD reveals that full vaccination has an 80,4% effectiveness in a broad population with diverse exposure to immunosuppressive therapies.
Results of a randomized controlled trial indicate that patients with discontinued infliximab therapy have a relapse rate of 45,7% within 48 weeks as compared to 19,6% in patients receiving continued infliximab therapy.
Accuracy of transient elastography at diagnosis of PBC (and thus in naive patients) has not been defined. A current study demonstrates that advanced fibrosis can indeed be excluded (liver stiffness measurement ≤ 6.5 kPa) or confirmed (> 11.0 kPa) in many patients in this setting using transient elastography. However, transient elastography is not reliable between these 2 cut-offs, and a liver biopsy may be necessary. BMI and liver biochemistry did not affect transient elastography.
There are numerous non-invasive scoring systems for predicting fibrosis in patients with NAFLD. A current study examined the predictive power of these scores for the long-term outcome (risk of fibrosis, liver-related complications, or death). The NAFLD fibrosis score (NFS), hepamet fibrosis score (HFS) and fibrosis 4 index (FIB-4) performed best.
Oesophagus Stomach Duodenum
European study confirms higher resistance against clarithromycin and levofloxacin in Central/Western and Southern as compared to Northern Europe, which correlates with higher consumption of macrolides and quinolones. These findings should be considered when choosing eradication therapies.
Approximately 10% of 878 patients with symptomatic EoE had macroscopically normal endoscopic findings, indicating that macroscopically normal findings should not preclude biopsies.
Epidermal growth factor receptor (EGFR) amplification and outcome in a randomized phase III trial of chemotherapy and panitumumab
EGFR copy numbers were accurately measured in tumor tissues and liquid biopsies and may be used to predict response to chemotherapy and prognosis.
A meta-analysis involving 55 trials and 17,062 patients revealed that rectal diclofenac (100 mg) was the best performing rectal non-steroidal anti-inflammatory drug. Combinations with intravenous fluid therapies or pancreatic stenting may further increase the efficacy.