Revista Gastroenterología

May 2020

Who get’s EoE? – Part I: Individual & epidemiological risk factors

• The most important facts summarized: • The most important facts summarized:Which reasons might play a role for an individual patient to get eosinophilic esophagitis (EoE)? • Allergic triggers from food and the environment • Allergic comorbidities like asthma, hay fever or eczema • The exact reasons are not yet finally determined • Can we learn something about EoE from epidemiological data? • Risk factors can be allergic diseases, certain climate zones (cold and arid), vegetation and aeroallergens • In rural areas the risk can be higher due to pesticides...

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Anti-TNF therapy in patients with previous cancer diagnosis

Results of a population based study indicate that therapy with TNF antibodies in patients with chronic inflammatory diseases and previous cancer diagnosis does not influence the risk of recurrent or primary cancer development. Also timing of TNF inhibitor therapy does not affect cancer risk.

Non-invasive markers to monitor endoscopic Crohn’s disease activity

The endoscopic healing index (EHI) based on serum concentrations of 13 proteins identified patients in endoscopic remission and patients with resolution of endoscopic disease activity with good accuracy. However, the score is affected by disease duration, comparable to analysis of fecal calprotectin and superior to measurement of serum C-reactive protein.


Non-alcoholic fatty liver disease (NAFLD):

A retrospective cohort study indicates that each additional metabolic trait increases the risk of cirrhosis and hepatocellular carcinoma (HCC). Diabetes confers the highest risk of progression to HCC. These results may help to prioritize patients for secondary prevention programs.

Oesophagus Stomach Duodenum

Gastric intestinal metaplasia (GIM)

Results of an American retrospective study indicate that the point prevalence of GIM is high (11.7%) and that GIM particularly affects non-white and Hispanic Americans. In patients with GIM, increasing age and male gender were predominant risk factors for progression to dysplasia or gastric cancer.


Current Falk literature:




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