FMT appears safe with low risk of transmission of infections in a cohort study involving 609 cases. However, several new diagnoses were reported, which should be explored in future prospective studies.
Anti-SARS-CoV-2 antibody responses in inflammatory bowel disease (IBD) patients treated with infliximab:
Infliximab was associated with attenuated serological responses to SARS-CoV-2 infection, that were further blunted by immunomodulators used as concomitant therapy in a large British cohort study.
The transplantation of livers from donors after circulatory death is associated with an increased risk of non-anastomotic biliary strictures. A current prospective, randomized study shows that hypothermic oxygenated machine perfusion lowers the risk of non-anastomotic biliary strictures in this constellation compared to conventional static cold storage.
A recent multicenter retrospective analysis shows that magnetic resonance imaging (MRI) is superior to ultrasound for the detection of early-stage cholangiocarcinoma (CCA). Diagnosing CCA by MRI before the onset of symptoms is associated with improved outcomes.
The benefit of HCV therapy in patients with advanced liver cirrhosis is controversial. A recent study shows that treatment response is associated with a reduced risk of disease progression in patients with Child-Pugh A cirrhosis, but not in patients with Child-Pugh B/C cirrhosis. In Child-Pugh B/C cirrhosis, 19% of patients displayed a MELD (Model of End-stage Liver Disease) score decrease of ≥ 2 points, but this did not lead to an improved clinical outcome.
Oesophagus Stomach Duodenum
Results of 3 independent patient cohorts show that IgA transglutaminase titers of ≥ 10 x ULN have a strong predictive value to identify adults with intestinal changes diagnostic of celiac disease, thereby supporting a no-biopsy diagnostic approach.
The findings of a trial from Bangladesh suggest that MDCF-2, a prebiotic dietary supplement, improves body growth in children with acute moderate malnutrition, suggesting that manipulation of the microbiota may be linked to growth.
Aggressive hydration therapy in addition to rectal non-steroidal anti-inflammatory drugs (NSAID) did not reduce the PEP incidence as compared to rectal NSAID alone.