Revista Gastroenterología

June 2021


Effect of IBD medications on COVID-19 outcomes

Combination therapy and monotherapy with thiopurines may be associated with an increased risk of severe COVID-19 as compared to TNF antibodies. There were no differences between the individual biologicals.


Liver transplantation (LT)

The transplantation of livers from donors after circulatory death is associated with an increased risk of non-anastomotic biliary strictures. A current prospective, randomized study shows that hypothermic oxygenated machine perfusion lowers the risk of non-anastomotic biliary strictures in this constellation compared to conventional static cold storage.

Primary sclerosing cholangitis (PSC):

A recent multicenter retrospective analysis shows that magnetic resonance imaging (MRI) is superior to ultrasound for the detection of early-stage cholangiocarcinoma (CCA). Diagnosing CCA by MRI before the onset of symptoms is associated with improved outcomes.

Hepatitis C virus (HCV):

The benefit of HCV therapy in patients with advanced liver cirrhosis is controversial. A recent study shows that treatment response is associated with a reduced risk of disease progression in patients with Child-Pugh A cirrhosis, but not in patients with Child-Pugh B/C cirrhosis. In Child-Pugh B/C cirrhosis, 19% of patients displayed a MELD (Model of End-stage Liver Disease) score decrease of ≥ 2 points, but this did not lead to an improved clinical outcome.

Oesophagus Stomach Duodenum

Serology-based diagnostics of celiac disease in adults:

Results of 3 independent patient cohorts show that IgA transglutaminase titers of ≥ 10 x ULN have a strong predictive value to identify adults with intestinal changes diagnostic of celiac disease, thereby supporting a no-biopsy diagnostic approach.

Medical therapy for obesity

Once-weekly injections of the GLP-1 analogue semaglutide plus life style interventions in a phase 3 trial were associated with sustained and clinically meaningful reductions in body weight.




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