Revista Gastroenterología

January 2022



Proton-pump inhibitors in hereditary hemochromatosis:

Proton-pump inhibitors (PPIs) are currently linked to an unfavorable course of several conditions. In hereditary, HFE-associated hemochromatosis, however, PPI therapy can reduce the phlebotomy burden, presumably by inhibiting iron absorption.

Mortality risk in autoimmune hepatitis (AIH):

A current nationwide population-based cohort study from Sweden shows that AIH is associated with a 2-fold increased risk of death even today. However, mainly cirrhosis and portal hypertension at first diagnosis as well as overlap with cholestatic liver disease contribute to this unfavorable outcome.

Hepatitis C virus (HCV):

 Protease inhibitor (PI)-based direct-acting antiviral (DAA) therapy is contraindicated in patients with advanced liver cirrhosis due to the risk of liver decompensation. A current cohort study suggests, however, that PIs are associated with an increased rate of transaminase elevation > 200 U/l, but not with severe liver dysfunction or liver decompensation. Further studies should therefore clarify whether patients with advanced cirrhosis can be safely treated with a PI-based DAA regimen. This would enable new therapeutic options for patients who failed on a non-PI-based therapy.

Oesophagus Stomach Duodenum

Adjustable intragastric balloon for treatment of obesity:

An adjustable intragastric balloon in combination with lifestyle modifications resulted in a sustained weight loss, which was achieved and maintained for 6 months following removal. Balloon volume adjustability permitted individualized therapy, maximizing weight loss and tolerance.




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