Revista Gastroenterología

February 2022

Bowel

Oral CBD-rich cannabis for Crohn’s disease:

Eight weeks of cannabidiol (CBD)-rich cannabis treatment induced significant clinical and quality-of-life improvement without significant changes in inflammatory parameters or endoscopic scores in a placebo-controlled trial with Crohn’s disease patients.

Dietary therapy for adult patients with Crohn’s disease:

Crohn’s disease exclusion diet with or without partial enteral nutrition was effective for induction and maintenance of remission in biological-naive adults with mild-to-moderate active Crohn’s disease and even induced endoscopic remission in a subset of patients.

Liver

Outcome of pregnancy in autoimmune hepatitis: favorable prognosis, but increased risk of complications:

A recent American population-based study shows that autoimmune hepatitis in pregnancy is associated with significant maternal and perinatal risks such as gestational diabetes, hypertensive complications (pre-eclampsia, eclampsia and HELP syndrome with hemolysis, elevated liver enzymes and low platelet count) and premature birth. However, autoimmune hepatitis is not associated with postpartum hemorrhage, maternal, or perinatal death.

Transfusion-transmitted hepatitis E virus infection: residual risk depending on screening method:

Screening of blood donors for hepatitis E virus (HEV) RNA with a limit of detection (LOD) of 2000 IU/ml is currently mandatory in Germany. A recent study shows that when using this little sensitive detection limit (e.g. when testing samples in pools), only 73% of HEV transmissions by red blood cell concentrates and only 42% of HEV transmissions by platelet and fresh plasma transfusions can be prevented.

Oesophagus Stomach Duodenum

Outcomes of seronegative celiac disease:

A 20-year multicenter follow-up study demonstrates that seronegative celiac disease has a more aggressive disease phenotype and a higher mortality than seropositive celiac disease. These data argue against over-reliance on serology for the diagnosis of celiac disease.

Pancreas

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