A large English cohort study suggests that oral antibiotic use is associated with a significantly increased risk to develop colon carcinoma, but reduced risk for rectal cancer. These results may suggest different functions of the gut microbiota in tumor pathogenesis along the large intestine.
A randomized trial indicates that endoscopic clip closure of the mucosal defect following resection of large colon polyps reduces risk of postprocedure bleeding. The protective effect appeared to be restricted to large polyps located in the proximal colon.
A large English cohort study suggests that oral antibiotic use is associated with a significantly increased risk to develop colon carcinoma, but reduced risk for rectal cancer. These results may suggest different functions of the gut microbiota in tumor pathogenesis along the large intestine.
A current phase 3 trial demonstrates the efficacy of obeticholic acid, especially in improving fibrosis. This effect was most prominent, however, at a higher dose (25 mg daily) that was associated with mostly mild to moderate pruritus in approx. 50% of patients.
A current study from Hong Kong analyzed the risk of HBV reactivation and hepatitis flares after steroid treatment. HBV reactivation occurred in 1.8% of patients with “resolved” hepatitis B within 1 year; within 10 years, the risk was 5.5% in patients with anti-HBc only. More common, however, was the occurrence of HBV-independent hepatitis flares (11.9% within 1 year), with a dose > 20 mg prednisolone equivalents and treatment duration > 7 days as risk factors.
A current prospective cohort study in 51 pregnancies of women with HCA < 5 cm showed that HCA increased in size during a quarter of pregnancies with a median increase of 14 mm. Clinically relevant complications such as bleeding, however, occurred in none of the pregnancies. Thus, HCA < 5 cm confer minimal risk to a pregnant woman and her child.
Results of a phase 2 trial suggest that oral immunotherapy with 4000 mg peanut protein can effectively desensitize individuals with peanut allergy, but discontinuation or dose reduction could increase the risk of regaining clinical reactivity to peanut. Moreover, allergological lab test results at baseline predicted response to desensitization and could be useful for selecting the appropriate patient population.
In a randomized trial, peroral endoscopic myotomy (POEM) was non-inferior to laparoscopic myotomy and fundoplication in controlling symptoms of achalasia, but gastrointestinal reflux was more common following POEM.
A real-time artificial intelligence system achieved high diagnostic accuracy in detecting upper gastrointestinal cancers with sensitivity similar to expert endoscopists and superior to that of competent endoscopists or trainees.
A small trial indicates that pancreatic duct stenting is technically difficult, associated with an unacceptably high risk of pancreatic necrosis infection and should be avoided.
Primary sclerosing cholangitis (PSC) Compiled by: T. Berg, T. Herta (32 pages) U82EPSC
Read moreLive Sessions
Webinars
© 2024 JNews - Premium WordPress news & magazine theme by Jegtheme.
Si ya esta registrado ingrese aquí
Si ya esta registrado ingrese aquí