Bowel
Influence of proton-pump inhibitor (PPI) therapy on the outcome of infliximab therapy in inflammatory bowel disease (IBD):
This patient-level meta-analysis of randomized controlled trials indicates that IBD patients taking PPI are less likely to achieve remission.
Endoscopic submucosal dissection (ESD) in Germany:
ESD achieved excellent en bloc resection rates but only modest curative resection rates in a German prospective ESD registry comprising 1000 lesions. Moreover, the results varied significantly depending on the center’s yearly case volume.
Ozanimod for ulcerative colitis:
The sphingosine-1-phosphate receptor modulator Ozanimod was more effective than placebo as induction and maintenance therapy in patients with moderately to severely active ulcerative colitis.
Liver
Steroids in alcohol-associated hepatitis (CONTRA):
A current observational study shows that both, patients with severe alcohol-associated hepatitis as well as patients with decompensated alcohol-associated cirrhosis are very susceptible to infection. Patients with severe alcohol-associated hepatitis or a high MELD score (model for end-stage liver disease) have a particularly high risk. However, the main risk factor for invasive fungal infection is steroid treatment, not severe alcohol-associated
Steroids in alcohol-associated hepatitis (PRO):
A recent retrospective, international, multicenter cohort study shows that steroids improve 30-day survival in patients with severe alcohol-associated hepatitis, especially those with a MELD score (model for end-stage liver disease) between 25 and 39.
Non-alcoholic fatty liver disease (NAFLD):
A current prospective study demonstrates the important impact of fibrosis stage on prognosis of NAFLD: Fibrosis stages F3 and F4 are associated with increased risks of liver-related complications (variceal hemorrhage, ascites, encephalopathy, or hepatocellular carcinoma) and death.
Oesophagus Stomach Duodenum
Association between proton-pump inhibitor (PPI) use and gastric cancer:
Analysis of a population-based cohort study from Korea suggest that PPI use is associated with an approx. 2,37-fold increased risk of subsequent gastric cancer. These findings were irrespective of Helicobacter pylori eradication status.
Diet quality and risk and severity of COVID-19:
A diet characterized by plant-based foods was associated with lower risk and severity of COVID-19. This association may be particularly evident in patients living in areas with higher socioeconomic deprivation.
Over-the-scope clips (OTSC) as initial treatment of severe non-variceal upper gastrointestinal bleeding:
In a small randomized trial with 53 patients, OTSC significantly reduced rates of rebleeding, severe complications and transfusions as compared to conventional endoscopic hemostasis.
Pancreas
Immediate versus postponed intervention for infected necrotizing pancreatitis:
This randomized trial did not show a superiority of immediate drainage with regard to complications or mortality. However, patients assigned to postponed-drainage strategy received fewer invasive interventions.
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