Revista Gastroenterología

April 2022

Bowel

Liver

Updated efficacy and safety data of atezolizumab plus bevacizumab versus sorafenib in unresectable hepatocellular carcinoma:

Even after an additional 12-months follow-up of the IMbrave150 study, atezolizumab plus bevacizumab maintained clinically meaningful survival benefits over sorafenib. After a median 15.6 (range, 0–28.6) months of follow-up, the median overall survival was 19.2 months (95% confidence interval : 17.0–23.7) with atezolizumab plus bevacizumab and 13.4 months (95% CI: 11.4–16.9) with sorafenib (hazard ratio = 0.66; 95% CI: 0.52–0.85; descriptive p < 0.001).

International Autoimmune Hepatitis Group proposes criteria for response to therapy in autoimmune hepatitis:

A consensus process initiated by the International Autoimmune Hepatitis Group (IAIHG) proposes the following criteria: Complete biochemical response: normalization of serum transaminases and immunoglobulin G (IgG) below the upper limit of normal at 6 months after initiation of treatment.Insufficient response by 6 months: failure to meet the above definition.Non-response: < 50% decrease of serum transaminases within 4 weeks after initiation of treatment.Remission: liver histology with a Hepatitis Activity Index < 4/18.Intolerance to treatment: any adverse event possibly related to treatment leading to potential drug discontinuation.

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