A simple and highly reproducible index for histologial remission in ulcerative colitis based on chromoendoscopy:
The simple “Paddington International virtual ChromoendoScopy ScOre“ (PICaSSO) histological remission index exhibited the highest correlation with endoscopic activity and clinical outcomes and may be used in artificial intelligence algorithms to predict histological remission.
Safe pregnancy after liver transplantation: Evidence from a multicenter Italian collaborative study:
A recent multicenter collaborative Italian study confirms that pregnancies in liver transplant recipients are associated with an increased risk of maternal complications and premature births, however have a good outcome.
A recent case simulation study confirms the value of liver biopsy in diagnosis of drug-induced liver injury (DILI):
The study shows that liver histology is particularly helpful in cholestatic or equivocal cases of DILI and shifts the evaluation in "possible" or "probable" DILI cases towards "certain/very likely" or "unlikely".
Non-alcoholic fatty liver disease (NAFLD) and risk for hepatocellular carcinoma (HCC): Role of diabetes medications and glycemic control:
A large American retrospective cohort study shows that metformin is associated with a reduced HCC risk in NAFLD patients, while a combination therapy of insulin and other oral antidiabetics is associated with an increased risk. Adequate glycemic control is also linked to a significantly reduced HCC risk.
Oesophagus Stomach Duodenum
Compared to placebo, adding gluten to the diet did not induce gastrointestinal complaints or worsened mental health in adolescents recruited from a population-based cohort.
The diagnostic yield of pancreatic adenocarcinoma by endosonography and magnetic resonance imaging was substantial in established high-risk mutation carriers, but non-existent in mutation-negative patients with familial cancer risk.